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Title: A Nanofibrous Phbv Tube with Schwann Cell as Artificial Nerve Graft Contributing to Rat Sciatic Nerve Regeneration across a 30-Mm Defect Bridge
Journal: Cell communication & adhesion
Author: 1. Esmaeil Biazar, 2,3. Saeed Heidari Keshel
Year: 2013
Address: 1. Department of Biomaterial Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran, 2 Student Research Committee, 2. Student Research Committee, Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 3. Tissue Engineering Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Abstract: A nanofi brous PHBV nerve conduit has been used to evaluate its effi ciency based on the promotion of nerve regeneration in rats. The designed conduits were investigated by physical, mechanical and microscopic analyses. The conduits were implanted into a 30-mm gap in the sciatic nerves of the rats. Four months after surgery, the regenerated nerves were evaluated by macroscopic assessments and histology. This polymeric conduit had suffi ciently high mechanical properties to serve as a nerve guide. The results demonstrated that in the nanofi brous graft with cells, the sciatic nerve trunk had been reconstructed with restoration of nerve continuity and formatted nerve fi bers with myelination. For the grafts especially the nanofi brous conduits with cells, muscle cells of gastrocnemius on the operated side were uniform in their size and structures. This study proves the feasibility of artifi cial conduit with Schwann cells for nerve regeneration by bridging a longer defect in a rat model.
Keywords: sciatic regeneration , schwann cell , artifi cial conduit , nanofi brous PHBV , histological assessments
Application: Tissue Engineering
Product Model 1: Electroris
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URL:"" & "/doi/full/10.3109/15419061.2013.774378"#