ISI Papers With Our Products



Title: Behavioral Evaluation of Regenerated Rat Sciatic Nerve by a Nanofibrous Phbv Conduit Filled with Schwann Cells as Artificial Nerve Graft
Journal: Cell communication & adhesion
Author: 1. Esmaeil Biazar, 2,3. Saeed Heidari Keshel, 4. Majid Pouya
Year: 2013
Address: 1. Department of Biomaterial Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran 2. Faculty of Paramedical Sciences, Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 4. Faculty of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
Abstract: The aim of this study is to develop a nanofi brous polymeric nerve conduit with Schwann cells (SCs) and to evaluate its effi ciency on the promotion of functional and locomotive activities in rats. The conduits were implanted into a 30-mm gap in the sciatic nerves of the rats. Four months after surgery, the rats were monitored and evaluated by behavioral analyses such as toe out angle, toe spreading analysis, walking track analysis, extensor postural thrust, open-fi eld analysis, swimming test and nociceptive function, four months post surgery. Four months post-operatively, the results from behavioral analyses demonstrated that in the grafted groups especially in the grafted group with SCs, the rat sciatic nerve trunk had been reconstructed with functional recovery such as walking, swimming and recovery of nociceptive function. This study proves the feasibility of artifi cial conduit with SCs for nerve regeneration by bridging a longer defect in the rat model.
Keywords: peripheral nerve , sciatic nerve , nanofibrous PHBV conduit , Schwann cells , behavioral analysis
Application: Tissue Engineering
Product Model 1: Electroris
Product Model 2:
URL: http://www.tandfonline.com/doi/abs/10.3109/15419061.2013.833191#="http://www.tandfonline.com" & "/doi/abs/10.3109/15419061.2013.833191"#