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Title: Drug-loaded electrospun nanofibrous sheets as barriers against postsurgical adhesions in mice model
Journal: Nanomedicine Research Journal
Author: 1. Safieh Boroumand, Reza Faridi-Majidi, 2. Sara Hosseini, Mohammad Salehi
Year: 2017
Address: 1. Department of Medical Nanotechnology, School of Advanced Technology in Medicine, Tehran University of Medical science, Tehran, Iran 2. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract: Objective(s): Postsurgical adhesion is one of the common complications after surgery. Some anti-adhesion barriers are commercially available which are not customarily used by physicians as much as expected because of ineffectiveness. Recently, nanofibers have been introduced as anti-adhesion barriers with the potential of drug delivery. In the light of role of inflammation and oxidative stress in adhesion formation, it is supposed that curcumin as an anti-oxidant and antiinflammatory agent is able to prevent postsurgical adhesions. Methods: In the present study, curcumin-loaded nanofibrous sheets were prepared using electrospinning and evaluated for its anti-adhesion profile in a mice model. Scanning Electron Microscopy (SEM), Attenuated Total Reflectance Fourier Transformed Infrared Spectroscopy (ATR-FTIR), drug release and degradation investigations and also, in vivo studies were performed. Results: curcumin-loaded nanofibers were successfully prepared and shown significant prevention of postsurgical adhesion formation in mice model. Release study indicated that after 30 days, about 30% of the drug is released from the electrospun nanofibers. In vivo experiments showed that postsurgical adhesion has been reduced about 50% compared to the control group. Conclusions: Curcumin-loaded nanofibers have the potential to decrease postsurgical adhesion formation as a barrier. This system supports the sustained release of curcumin from the nanofibers.
Keywords: Postsurgical adhesion Electrospinning Curcumin
Application: Drug Delivery
Product Model 1: Electroris
Product Model 2:
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