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Title: An investigation of electrospun Henna leaves extract-loaded chitosan based nanofibrous mats for skin tissue engineering
Journal: Materials Science and Engineering: C
Author: 1,5. Iman Yousefi, 2. Mehdi Pakravan, 3. Hoda Rahimi, 4. Abbas Bahador, Zahra Farshadzadeh, 5,6,7. Ismael Haririan
Year: 2017
Address: 1. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran 2. Department of Chemical Engineering, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada 3. Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran 4. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 5. Medical Biomaterials Research Center (MBRC), Tehran University of Medical Sciences, Tehran, Iran 6. Department of Pharmaceutical Biomaterial, Tehran University of Medical Sciences, Tehran, Iran 7. Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Abstract: Wound healing characteristics of some plant extracts have been well known for many years, and they have been utilized for such applications in traditional way. Recently electrospun nanofibrous mats showed promising properties for tissue engineering and especially for skin repair. It is expected that incorporation of plant extracts into such structures could provide higher performance and synergistic effect for biomedical and wound healing applications. The final purpose of this study is to fabricate chitosan based nanofiber mats loaded with a traditional plant extract of Lawsonia inermis (Henna) leaves to enhance the antibacterial efficacy and wound healing of the precursor nanofibers. The morphology, structure, mechanical properties and swelling and weight loss degree of the electrospun nanofibers have been investigated in this study. Antibacterial activity, cell biocompatibility evaluations and in vivo wound healing activity of the abovementioned mats were also studied. The FESEM images of Henna leaves extract-loaded nanofibers proved that homogeneous, smooth and defect free nanofibers of 64–87 nm in diameter have been prepared. Presence of Henna extract in the electrospun fibers was approved by Fourier Transform Infrared spectroscopy. Incorporation of Henna extract into the nanofiber mats exhibited significant synergistic antibacterial activity against bacterial cells. It was well supported by the results of cell viability and proliferation of human foreskin fibroblast cells on the prepared scaffolds. Therefore, the results of this work showed that Henna leaves extract incorporated chitosan nonwoven mats have a great potential to be used as the biodegradable, biobased and antibacterial wound healing dressings.
Keywords: Electrospinning, Nanofiber, Chitosan, Lawsonia inermis, Henna extract, and Wound Healing
Application: Tissue Engineering, Wound Dressing
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