ISI Papers With Our Products
Title: Effect of solution and apparatus parameters on the morphology and size of electrosprayed PLGA microparticles
Journal: Fibers and Polymers
Author: 1. Abdol-Rahim Faramarzi, Jalal Barzin, 2. Hamid Mobedi
Year: 2016
Address: 1. Biomaterials Department, Iran Polymer and Petrochemical Institute, Tehran 14977-131115, Iran
2. Novel Drug Delivery Systems Department, Iran Polymer and Petrochemical Institute, Tehran 14977-131115, Iran
Abstract: Because of a number of facilities, the Electrospray (ES) method is gaining ever-increasing popularity among
researchers for producing nano-to-micron-sized particles. Microparticles (MPs) of poly lactic-co-glycolic acid (PLGA) were
prepared by using the ES technique. The influence of both solution and apparatus parameters on the morphology, size, size
distribution, and uniformity of produced MPs were investigated. Results of SEM images and calculations revealed that
polymer concentration is a critical parameter in the ES system. In a semi-dilute moderately entangled regime, chain
entanglement can easily occur. Solution flow rate is a key factor among apparatus parameters. Vapour pressure is a key
parameter affecting MP morphology. The size of the particles tended to reduce with an increase in voltage. The needle gauge
did not have an important impact on particle size. The role of the electric field changed at different collecting distances. Using
a saturated combination of EtOH/PVA is an acceptable collecting medium for PLGA MPs. It is possible to produce uniform
and spherical MPs by using chloroform as a solvent. However, a reduction in particle size is achievable by using a solvent of
chloroform/DMF (90/10 w/w).
Keywords: Poly lactic-co-glycolic acid, Electrospray, Morphology, Size, Uniformity
Application: Microparticle, Drug Delivery
Product Model 1: Syringe Pump (SP1000)
Product Model 2: High Voltage Power Supply (HV35POC)
URL: http://link.springer.com/article/10.1007/s12221-016-6685-3#="http://link.springer.com" & "/article/10.1007/s12221-016-6685-3"#