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Title: Fabrication and characterization of chitosan beads as a controlled release drug delivery system of theophylline
Journal: structure
Author: 1. Movaffagh J., 2. Sajadi Tabassi S.A., 3. Rastgoo A., 4. Amiri N., 5. Shariatnia F.
Year: 2014
Address: 1. Targeted Drug Delivery Research Center, Stem Cell Center and Dept. of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775-1365, Mashhad, Iran 2. Pharmacological Research Center of Medicinal Plants, School of Medicine and Dept. of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran 3. Dept. of enviromental health, School of health, Mashhad University of Medical Sciences, Mashhad, Iran 4. Targeted Drug Delivery Research Center, Dept. of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran 5. Targeted Drug Delivery Research Center, pharm D student, School of Pharmacy, Mashhad University of Medical Sciences,
Abstract: Chitosan is a biodegradable and biocompatible polymer which has received much attention in recent years as an oral drug delivery vehicle for controlled-release formulations. In the present study chitosan beads were prepared by an ionotropic gelation method with tripolyphosphate (TPP) and loaded with theophylline using high MW of chitosan. The beads were characterized for shape and surface morphology by electron microscope. Loading efficiency of beads was determined by UV spectrophotometric method. Drug release profile and swelling behavior were studied in buffer pH 7.4. The results of this study showed that chitosan beads with nearly spherical shape and smooth surfaces with about 93% drug loading. Swelling studies revealed that chitosan beads were able to absorb 1.5 fold as much water as their initial weight. Drug release profile from chitosan beads showed that the release of theophylline increases with time with a steeper slope up to 6 hours and levels off afterwards reaching 30% in 12 hours. This means that a sustained release system of theophylline has been obtained which can release the drug in a slow yet continuous manner. The beads were 3-4 mm in diameter. It can be concluded that chitosan can be used as a biomaterial vehicle for preparation of controlled release beads loaded with theophylline. It was shown that the release of theophylline from chitosan beads has a two phase pattern and controlled by more than one mechanism.
Keywords:
Application: Drug Delivery
Product Model 1: Syringe Pump (SP1000)
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URL: http://www.ari.ir/abstractspdf/959.pdf#="http://www.ari.ir" & "/abstractspdf/959.pdf"#