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Title: Drug delivery and cytocompatibility of ciprofloxacin loaded gelatin nanofibers-coated Mg alloy
Journal: Materials Letters
Author: 1. H.R. Bakhsheshi-Rad, 2. Z. Hadisi, M. Kashefian, 3. E. Hamzah, 4. A.F. Ismail, M. Aziz
Year: 2017
Address: 1. Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran 2. Biomaterials Group, Faculty of New Science and Technologies, University of Tehran, Tehran, Iran 3. Department of Materials, Manufacturing and Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Johor, Malaysia 4. Advanced Membrane Technology Research Center (AMTEC), Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Johor, Malaysia
Abstract: In this study, gelatin-ciprofloxacin (Gel-Cip) nanofibers containing various amounts of Cip (0, 2, 4 and, 8 wt%) were fabricated on the surface of Mg-1Ca alloy via an electrospinning process. Microscopic characterization indicated a porous network structure with fiber diameters in the range of 150–170 nm. Prolonged drug release was attained from Gel-Cip nanofibers coating along with initial rapid drug release of around 20–22% during 12 h, followed by a slow release stage that can effectively control the infection. The incorporation of 2–4 wt% Cip into Gel nanofibers coating significantly increased the antibacterial performance and corrosion resistance of the uncoated Mg-Ca alloy without showing an inhibitory influence on the cytocompatibility characteristic. Hence, it is potentially appropriate as the novel electrospun nanofibers coating material for bone regeneration application.
Keywords: Electrospinning, Gelatin nanofibers, Ciprofloxacin, Antimicrobial activity, Cytocompatibility
Application: Drug Delivery
Product Model 1: Electroris
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