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Title: Enhanced sciatic nerve regeneration by human endometrial stem cells in an electrospun poly (ε- caprolactone)/collagen/NBG nerve conduit in rat
Journal: Artificial cells, nanomedicine, and biotechnology
Author: 1. Forouzan Mohamadi, Somayeh Ebrahimi-Barough, Majid Salehi, Jafar Ai, 2. Mohammad Reza Nourani, 3. Korosh Mansoori, 4. Ali Akbar Alizadeh, 5. Seyed Mohammad Tavangar, 6. Farshid Sefat, 7. Siavash Sharifi
Year: 2017
Address: 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Nano Biotechnology Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran 3. Neuromusculoskletal Research Centre Firozgar Hospital, Iran University of Medical Sciences, Tehran, Iran 4. Department of Tissue Engineering and Applied Cell Sciences, Shiraz University of Medical Sciences, Shiraz, Iran 5. Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran 6. Department of Medical Engineering, School of Engineering, University of Bradford, Bradford, UK 7. Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
Abstract: In recent years, for neurodegenerative diseases therapy, research has focused on the stem cells therapy. Due to promising findings in stem cell therapy, there are various sources of stem cells for transplantation in human. The aim of this study was to evaluate sciatic nerve regeneration in the rat after nerve transaction followed by human endometrial stem cells (hEnSCs) treatment into poly (e-caprolactone)/ collagen/nanobioglass (PCL/collagen/NBG) nanofibrous conduits. After treatment of animals, the performance in motor and sensory tests, showed significant improvement in rats treated with hEnSCs as an autograft. H&E images provided from cross-sectional and, longitudinal-sections of the harvested regenerative nerve as well as immunohistochemistry results indicated that regenerative nerve fibres had been formed and accompanied with new blood vessels in the conduit cell group. Due to the advantage of high surface area for cell attachment, it is reported that this electrospun nerve conduit could find more application in cell therapy for nerve regeneration in future, to further improve the functional regeneration outcome, especially for longer nerve defect restoration. In conclusion, our results suggest that the PCL/collagen/NBG nanofibrous conduit filled with hEnSCs is a suitable strategy to improve nerve regeneration after a nerve transaction in rat.
Keywords: Tissue engineering; human endometrial stem cells; electrospinning, nanofibrous conduits, nerve regeneration
Application: Tissue Engineering
Product Model 1: Electroris
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