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Title: Taurine-loaded poly (ε-caprolactone)/gelatin electrospun mat as a potential wound dressing material: In vitro and in vivo evaluation
Journal: Journal of Bioactive and Compatible Polymers
Author: 1. Saeed Farzamfar, Hadi Samadian, 2. Mahdi Naseri-Nosar, Roksana Tajerian, Ahmad Vaez, 3. Simin Mahakizadeh, 4. Majid Rahmati, 5. Majid Salehi
Year: 2017
Address: 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Departments of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 3. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 4. Department of Medical Biotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran 5. Tissue Engineering and Stem Cell Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
Abstract: In this study, taurine (2-aminoethane sulfonic acid), an amino acid found in large amounts in most mammalian tissues, was incorporated with poly (ε-caprolactone) and gelatin in order to develop a drug-loaded composite wound dressing material. The composite mats from poly (ε-caprolactone)/ gelatin (1:1 (w/w)) solution incorporated with 3%, 5%, and 10% (w/w) of taurine were produced by electrospinning. The electrospun mats were evaluated regarding their morphology, wettability, water uptake capacity, water vapor transmission rate, tensile strength, and cellular response with L929 cell line. The mat containing 5% of taurine was chosen as the optimum dressing for in vivo study on the full-thickness excisional wounds of Wistar rats. The results showed that after 2 weeks, the wounds treated with the taurine-loaded dressing achieved a significant closure to nearly 92% compared with the sterile gauze, as control, which showed nearly 68% of wound closure. The histological examination of the wounds revealed that the wounds treated with the taurine-loaded dressing had densely packed collagen fibers with parallel alignment. Whereas, the sterile gauze–treated wounds had loosely packed collagen fibers with an irregular arrangement. Our results provided evidence supporting the possible applicability of the taurine-loaded wound dressings for successful wound treatment.
Keywords: Electrospinning, gelatin, poly (ε-caprolactone), taurine, wound dressing
Application: Wound Dressing
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URL: #http://journals.sagepub.com/doi/abs/10.1177/0883911517737103#