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Title: Cerium oxide Nanoparticle-containing Poly (ε-caprolactone)/Gelatin Electrospun Film as a Potential Wound Dressing Material: In Vitro and In Vivo Evaluation
Journal: Materials Science and Engineering: C
Author: 1. Mahdi Naseri-Nosar, Ahmad Vaez, 2. Saeed Farzamfar, 3. Hamed Sahrapeyma, 4. Sadegh Ghorbani, 5. Farshid Bastami, 6. Majid Salehi
Year: 2017
Address: 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1417755469, Iran 2. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1417755469, Iran 3. Department of Biomaterial Engineering, Science and Research Branch, Islamic Azad University, Tehran 1477893855, Iran 4. Department of Anatomical Sciences, School of Medical Sciences, Tarbiat Modares University, Tehran 14115111, Iran 5. Research Institute of Dental Sciences, Dental School Shaheed Beheshti University of Medical Sciences, Tehran 1983969411, Iran 6. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud 3613773955, Iran
Abstract: In the present study, cerium oxide (CeO2) nanoparticles were incorporated into poly (ε-caprolactone)/gelatin films in order to develop a potential wound dressing material. The wound dressings were prepared by electrospinning of poly (ε-caprolactone)/gelatin (1:1 (w/w)) solutions containing 1.50%, 3% and 6% (w/w) CeO2 nanoparticles. The electrospun films were evaluated regarding their morphology, contact angle, water-uptake capacity, water vapor transmission rate, tensile strength and cellular response. The film containing 1.50% CeO2 nanoparticles was chosen as the optimal dressing for the in vivo study on full-thickness excisional wounds of rats. The study showed that after 2 weeks, the wounds treated with the CeO2 nanoparticle-containing dressing achieved a significant closure to nearly 100% compared with the sterile gauze with the nearly 63% of wound closure. Our results provided evidence supporting the possible applicability of CeO2 nanoparticle-containing wound dressing for a successful wound treatment.
Keywords: Cerium oxide, Electrospinning, Gelatin, Poly (ε-caprolactone), Wound dressing
Application: Wound Dressing
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