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Title: A New Strategy for Fabrication of Bone Scaffolds Using Electrospun Nano-Hap/Phb Fibers and Protein Hydrogels
Journal: Chemical Engineering Journal
Author: 1,2. Mehdi Sadat-Shojai, 2. Mohammad-Taghi Khorasani, 3. Ahmad Jamshidi
Year: 2016
Address: 1. Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran 2. Department of Biomaterials, Iran Polymer and Petrochemical Institute, Tehran, Iran 3. Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institute, Tehran, Iran
Abstract: Electrospinning is an effective technology for fabrication of ultrafine fibers suitable for a tissue engineering scaffold. A limiting factor of electrospun scaffolds is however their tightly packed network providing only a superficial porous structure. Alternatively, hydrogels can be used to create scaffolds with a well-interconnected porous structure; but these materials provide a poor mechanical stability and a very low bioactivity, failing to create suitable three-dimensional constructs for bone tissue engineering. In this study, we therefore developed a novel hybrid scaffold system in which an electrospun mat based on biodegradable polyhydroxybutyrate (PHB) and hydroxyapatite (HAp) was combined with a protein-based hydrogel in a single tri-layered scaffold. In the resulting construct, while the hydrogel layers provide a suitable environment for cell encapsulation, the incorporated fibers act as a strong backbone increasing the mechanical properties of the scaffold. According to the results, mechanical properties of the construct were much higher than traditional hydrogels. Moreover, bone cells inside the scaffold were highly viable, and infiltrated into the electrospun center after 14 days of encapsulation. Given the high strength and the ability to encapsulate cells, the new cell-laden tri-layered scaffold was expected to enhance bone regeneration in vivo.
Keywords: Bone scaffold, ECM, Electrospinning, Hydrogel, Mechanical properties, Bone tissue engineering
Application: Scaffold, Tissue Engineering
Product Model 1: Electroris
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