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Title: Poly (Ε-Caprolactone)/Triclosan Loaded Polylactic Acid Nanoparticles Composite: A Long-Term Antibacterial Bionanocomposite with Sustained Release
Journal: International journal of pharmaceutics
Author: 1. Babak Kaffashi, Saeed Davoodi, Erfan Oliaei
Year: 2016
Address: 1. School of Chemical Engineering, College of Engineering, University of Tehran, P.O. Box 11365-4563, Tehran, Iran.
Abstract: In this study, the antibacterial bionanocomposites of poly(ε-caprolactone) (PCL) with different concentrations of triclosan (TC) loaded polylactic acid (PLA) nanoparticles (30 wt % triclosan) (LATC30) were fabricated via a melt mixing process in order to lower the burst release of PCL and to extend the antibacterial property during its performance. Due to the PLA's higher glass transition temperature (Tg) and less flexibility compared with PCL; the PLA nanoparticles efficiently trapped the TC particles, reduced the burst release of TC from the bionanocomposites; and extended the antibacterial property of the samples up to two years. The melt mixing temperature was adjusted to a temperature lower than the melting point of LATC30 nanoparticles; therefore, these nanoparticles were dispersed in the PCL matrix without any chemical reaction and/or drug extraction. The sustained release behavior of TC from PCL remained unchanged since no significant changes occurred in the samples’ crystallinity compared with that in the neat PCL. The elastic moduli of samples were enhanced once LATC30 is included. This is necessary since the elastic modulus is decreased with water absorption. The rheological behaviors of samples showed appropriate properties for melt electro-spinning. A stable process was established, as the relaxation time of the bionanocomposites was increased. The hydrophilic properties of samples were increased with increasing LATC30. The proliferation rate of fibroblast (L929) cells was enhanced as the content of nanoparticles was increased. A system similar to this could be implemented to prepare long-term antibacterial and drug delivery systems based on PCL and various kind of low molecular weight drugs. The prepared bionanocomposites are considered as candidates for soft connective tissue engineering and long-term drug delivery.
Keywords: poly(ε-caprolactone), drug release, bionanocomposite, polylactic acid, triclosan, antibacterial
Application: Drug Delivery
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