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Title: Preparation of Pure Plla, Pure Chitosan, and Plla/Chitosan Blend Porous Tissue Engineering Scaffolds by Thermally Induced Phase Separation Method and Evaluation of the Corresponding Mechanical and Biological Properties
Journal: International Journal of Polymeric Materials and Polymeric Biomaterials
Author: 1. MAJID SALEHI, AMIR AMANI, MAHMOUD AZAMI, SHIMA TAVAKOL, HOSSEIN GHANBARI, 2. MAHDI NASERI NOSAR
Year: 2015
Address: 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Biomaterials and Tissue Engineering, Biomedical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
Abstract: The aim of this work was to prepare the scaffolds of pure poly (L-lactic acid) 3% (w=v), pure chitosan 3% (w=v), and PLLA= chitosan blend (1:5) 3% (w=v) using TIPS method and investigate their properties and application in tissue engineering. An in vitro degradation study of scaffolds showed the addition of chitosan to PLLA not only increased its degradation rate, but also slowed down its pH value reduction. Addition of chitosan to PLLA increased hydrophilicity, porosity, compressive properties, and cell viability of the scaffolds. The results indicate that among all scaffolds, the most appropriate candidate for tissue engineering is PLLA=chitosan blend.
Keywords: Chitosan, poly (L-lactic acid), thermal induced phase separation, tissue engineering scaffolds
Application: Scaffold, Tissue Engineering
Product Model 1: Syringe Pump (SP1000)
Product Model 2:
URL: http://www.tandfonline.com/doi/abs/10.1080/00914037.2014.1002093#="http://www.tandfonline.com" & "/doi/abs/10.1080/00914037.2014.1002093"#