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Title: Size Control in the Nanoprecipitation Process of Stable Iodine (127i) Using Microchannel Reactor—Optimization by Artificial Neural Networks
Journal: AAPS PharmSciTech
Author: 1. Mohamad Hosein Aghajani, 2. Ali Mahmoud Pashazadeh, Majid Assadi, 2,3,7. Mahdi Aghajani, 3,4. Seyed Hossein Mostafavi, 5. Shayan Abbasi, 6. Mohammad-Javad Hajibagheri-Fard
Year: 2015
Address: 1. Faculty of Advanced Medical Technology, Golestan University of Medical Sciences, Gorgan, Iran. 2. Department of Nanotechnology, The Persian Gulf Nuclear Medicine Research Center, The Persian Gulf Biomedical Sciences Institute, Bushehr University of Medical Sciences, Bushehr, Iran. 3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. 4. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. 5. Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran. 6. Shohadaye Khalije Fars Hospital, Bushehr University of Medical Sciences, Bushehr, Iran.
Abstract: In this study, nanosuspension of stable iodine (127I) was prepared by nanoprecipitation process in microfluidic devices. Then, size of particles was optimized using artificial neural networks (ANNs) modeling. The size of prepared particles was evaluated by dynamic light scattering. The response surfaces obtained from ANNs model illustrated the determining effect of input variables (solvent and antisolvent flow rate, surfactant concentration, and solvent temperature) on the output variable (nanoparticle size). Comparing the 3D graphs revealed that solvent and antisolvent flow rate had reverse relation with size of nanoparticles. Also, those graphs indicated that the solvent temperature at low values had an indirect relation with size of stable iodine (127I) nanoparticles, while at the high values, a direct relation was observed. In addition, it was found that the effect of surfactant concentration on particle size in the nanosuspension of stable iodine (127I) was depended on the solvent temperature.
Keywords: ANNs; microfluidic; nanoprecipitation; particle size; stable iodine
Application: Microchannel Reactor, Drug Delivery
Product Model 1: Syringe Pump
Product Model 2:
URL: https://link.springer.com/article/10.1208/s12249-015-0293-1#="https://link.springer.com" & "/article/10.1208/s12249-015-0293-1"#