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Title: Unrestricted Somatic Stem Cells Loaded in Nanofibrous Scaffolds as Potential Candidate for Skin Regeneration
Journal: International Journal of Polymeric Materials and Polymeric Biomaterials
Author: 1. Esmaeil Biazar, 2,3. S. Heidari Keshel
Year: 2014
Address: 1. Department of Biomedical Engineering , Tonekabon Branch, Islamic Azad University , Tonekabon , Iran 2. Proteomics Research Center, Faculty of Paramedical Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran 3. Tissue Engineering Department, School of Advanced Technologies in Medicine , Tehran University of Medical Sciences , Tehran , Iran
Abstract: The authors have demonstrated the ability of cord blood–derived unrestricted somatic stem cells (USSCs) and gelatin-modified PHBV scaffold to promote skin regeneration. The scaffolds were designed by electrospinning method and evaluated by different analyses. Results of physical and mechanical analyses also were shown a good resilience as a skin graft. In animal model; all groups excluding the control group exhibited the most pronounced effect on wound closure, with the statistically significant improvement in wound healing being seen at post-operative day 21. Thus, the grafting of nanofibrous scaffold loaded with USSC showed better results during the healing process of skin defects in rat models.
Keywords: Gelatin cross linking, nanofibrous PHBV scaffold, unrestricted somatic stem cells (USSCs), wound healing
Application: Scaffold, Wound Dressing
Product Model 1: Electroris
Product Model 2:
URL: http://www.tandfonline.com/doi/abs/10.1080/00914037.2013.879447#="http://www.tandfonline.com" & "/doi/abs/10.1080/00914037.2013.879447"#