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Title: Development of Chitosan-Crosslinked Nanofibrous Phbv Guide for Repair of Nerve Defects
Journal: Artificial cells, nanomedicine, and biotechnology
Author: 1. Esmaeil Biazar, 2,3. Saeed Heidari Keshel
Year: 2014
Address: 1. Department of Biomaterial Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran 2. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3. Tissue Engineering Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract: The aim of this study was to produce a chitosan-crosslinked nanofibrous biodegradable poly (3-hydroxybutyrate-co-3- hydroxyvalerate) (PHBV) nerve conduit. The artifi cial scaff old was designed by electrospinning method, and cross-linked with chitosan by chemical method. The scaff olds were evaluated by microscopic, physical, and mechanical analyses, and cell culture assays with Schwann cells. Results of analyses showed a good resilience and compliance with movement as a neural graft. Cellular experiments showed a better cell adhesion and growth inside the crosslinked nanofi brous scaff olds compared with un-crosslinked ones. This neural conduit appears to have the right organization for testing in vivo nerve tissue engineering studies.
Keywords: cell culture , chitosan-crosslinked nanofi brous PHBV , electrospinning , neural guide
Application: Tissue Engineering
Product Model 1: Electroris
Product Model 2:
URL:"" & "/doi/abs/10.3109/21691401.2013.832686"#