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Title: Human Unrestricted Somatic Stem Cells Loaded in Nanofibrous Pcl Scaffold and Their Healing Effect on Skin Defects
Journal: Artificial cells, nanomedicine, and biotechnology
Author: 1. Hoda Bahrami, 1,2. Saeed Heidari Keshel, 3. Aliakbar Jafari Chari, 4. Esmaeil Biazar
Year: 2015
Address: 1. Stem Cell Preparation Unit, Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran, 2. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 3. Faculty of Medical Sciences, Guilan University of Medical Sciences, Guilan, Iran, 4. Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
Abstract: Unrestricted somatic stem cells (USSCs) loaded in nanofi brous polycaprolactone (PCL) scaff olds can be used for skin regeneration when grafted onto full-thickness skin defects of rats. Nanofi brous PCL scaff olds were designed by the electrospinning method and crosslinked with laminin protein. Afterwards, the scaff olds were evaluated by scanning electron microscopy, and physical and mechanical assays. In this study, nanofi brous PCL scaff olds loaded with USSCs were grafted onto the skin defects. The wounds were subsequently investigated 21 days after grafting. Results of mechanical and physical analyses showed good resilience and compliance to movement as a skin graft. In animal models; study samples exhibited the most pronounced eff ect on wound closure, with statistically signifi cant improvement in wound healing being seen at 21 days post-operatively. Histological examinations of healed wounds from all samples showed a thin epidermis plus recovered skin appendages in the dermal layer for samples with cell. Thus, the graft of nanofi brous PCL scaff olds loaded with USSC showed better results during the healing process of skin defects in rat models.
Keywords: nanofi brous pcl scaff old , unrestricted somatic stem cells , wound healing , rat
Application: Scaffold
Product Model 1: Electroris
Product Model 2:
URL: http://www.tandfonline.com/doi/abs/10.3109/21691401.2015.1062390#="http://www.tandfonline.com" & "/doi/abs/10.3109/21691401.2015.1062390"#